2014 Fiscal Year Final Research Report
Identification of the genomic alterations in metastatic renal cell carcinoma.
| Project/Area Number |
24590416
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Human pathology
|
|---|
| Research Institution | Oita University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAKADA Chisato 大分大学, 医学部, 助教 (60379625)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 腎細胞癌 / 転移 / 遺伝子 |
|---|
| Outline of Final Research Achievements |
We performed array CGH analysis to analyze the genomic profiles of 20 cases of primary ccRCC and their corresponding metastases. We identified 32 chromosomal regions in which gene copy number alterations were detected more frequently in metastases than in the primary tumors. Among these 32 regions, 9p24.1-p13.3 loss was the most statistically significant alteration. Transcriptome analysis revealed that 2 out of 58 genes located at 9p24.1-p13.3 were downregulated due to gene copy number loss in ccRCCs. Reexpression of these 2 genes in ccRCC cell lines revealed that downregulation of NDUFB6 due to loss at 9p24.1-p13.3 may confer a growth advantage on metastatic ccRCC cells. On the basis of our present data, we propose that NDUFB6 is a possible tumor suppressor of metastatic ccRCCs.
|
| Free Research Field |
分子病理学
|
