2014 Fiscal Year Final Research Report
The role of membrane-type serine protease inhibitors in invasion/metastasis of lung cancer
| Project/Area Number |
24590419
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 肺癌 / LRP11 / HGF activator inhibitor / serine protease |
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| Outline of Final Research Achievements |
There has been no literature reports about LRP11 in lung cancer. In Northern blot, the brain and prostate tissue and testis in human normal tissue was observed gene expression, mild gene expression was observed in the lung. Gene expression of LRP11 was detected by RT-PCR in lung cancer cell lines. To test anti humna-LRP11 antibodies, we made COS-hLRP11 cells which have expression of human LRP11 protein in COS-7 cells. Immunohistochemically, the cytoplasm and cell membrane of adenocarcinoma, squamous cell carcinoma and small cell carcinoma using surgical material (FFPE tissue) are positive for LRP11 using the anti-human LRP11 antibodies. Currently, we have search role of LRP11, especially relevance of clinocopathological findings and expression of LRP11, in lung cancer, using immunohistochemical study and real-time PCR.
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| Free Research Field |
人体病理学
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