Involvement of Podoplanin/CLEC-2 in atherothrombosis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590420
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Nara Medical University (2014); University of Miyazaki (2012-2013)
• Principal Investigator: KINTA Hatakeyama 奈良県立医科大学, 医学部, 准教授 (60325735)
• Co-Investigator(Kenkyū-buntansha): 今村 卓郎 宮崎大学, 医学部内科学講座, 准教授 (60203329) ; 佐藤 勇一郎 宮崎大学, 医学部病理学講座, 助教 (90347055) ; 鶴田 敏博 宮崎大学, 医学部内科学講座, 助教 (10389570)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 人体病理 / 循環器 / 動脈硬化 / 心筋梗塞 / 免疫染色 / 吸引血栓 / 組織病理学 / real time PCR

Outline of Final Research Achievements

Podoplanin/CLEC-2 is a platelet aggregation factor. In this study, the role of Podoplanin/CLEC-2 system in the pathogenesis of atherothrombosis was investigated. Using directional atherectomy(DCA) samples of angina pectoris patients(n=220), aspirated thrombi from coronary arteries of acute myocardial infarction(AMI) patients(n=100) and coronary arteries(n=60) from autopsy samples, we demonstrated that Podoplanin/CLEC-2 was overexpressed in the atherosclerotic lesions, and involved in the pathogenesis of atherothrombosis/acute coronary syndromes.

Free Research Field

病理学