2014 Fiscal Year Final Research Report
Invasive pattern of pancreatic carcinoma: special reference to PanIN and IPMN
| Project/Area Number |
24590425
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | PanIN / IPMN / pancreatic cancer / gastric type / intestinal type / tissue microarray |
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| Outline of Final Research Achievements |
Pancreatic carcinomas is considered to be derived from either PanIN or IPMN. Especially, PanIN-3 is an important lesion, however; there may be de novo cancer present. Regarding the histologic type of pancreatic carcinoma, gastric type IPMN usually progressed to ordinary adenocarcinoma, whereas intestinal type IPMN mainly showed mucinous (colloid) carcinoma. When pancreatic cancer cells invaded into normal pancreas, pancreatic islets tended to be preserved to the end. Using Tissue Microarray method, pancreatic cancer cells could reveal focal positivity for HNF-1 beta, chromogranin A, p63 or BCL-10. These immunohistochemical results may have influence with histological variation of pancreatic cancer.
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| Free Research Field |
人体病理学
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