Factors related with carcinogenesis and invasion of ulcerative colitis-associated cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590426
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Toho University (2013-2014); Kitasato University (2012)
• Principal Investigator: MIKAMI Tetuo 東邦大学, 医学部, 教授 (90286352)
• Co-Investigator(Renkei-kenkyūsha): SATO Yuichi 北里大学, 医療衛生学部, 教授 (30178793)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 潰瘍性大腸炎 / 癌

Outline of Final Research Achievements

Carcinogenic　pathway　from　chronic　inflammation　is　considered　as　an　important　pathway.　Carcinogenesis in ulcerative colitis is one of the important diseases. We analyzed a cell adhesion molecule, CD44, in ulcerative colitis-associated neoplastic lesions,　dysplasia　and　cancer.　In　addition,　we　searched　for　proteins　which　are specifically up- or down-regulated in ulcerative colitis mucosa. As a result, CD44 was down regulated in ulcerative colitis-associated lesions, and its expression was considered to be associated with Adam17 expression. Carbonic anhydrase 2 was identified as one of the proteins down-regulated in ulcerative colitis mucosa.

Free Research Field

人体病理学