2015 Fiscal Year Final Research Report
Histopathological evaluation for pathogenesis of aortic aneurysm formation
| Project/Area Number |
24590435
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
Hao Hiroyuki 兵庫医科大学, 医学部, 准教授 (40393243)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 大動脈瘤 / 鉄代謝 / 動脈硬化 / 炎症 |
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| Outline of Final Research Achievements |
It has not been investigated whether iron plays a role in abdominal aortic aneurysm (AAA) formation through oxidative stress and inflammation. We examined whether iron is involved in the pathophysiology of AAA formation using human AAA walls and murine AAA models.Iron was accumulated in human and murine AAA walls compared with non-AAA walls. We next investigated the effects of dietary iron restriction on AAA formation in mice. Iron restriction reduced the incidence of AAA formation with attenuation of oxidative stress and inflammation.
Iron is involved in the pathophysiology of AAA formation with oxidative stress and inflammation. Dietary iron restriction could be a new therapeutic strategy for AAA progression.
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| Free Research Field |
循環器病理学
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