Role of CD146, a cell adhesion molecule, in early diagnosis and pathogenesis of malignant pleural mesothelioma

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590437
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Hyogo Medical University
• Principal Investigator: SATO AYUKO 兵庫医科大学, 医学部, 講師 (20419823)
• Co-Investigator(Kenkyū-buntansha): TSUJIMURA Tohru 兵庫医科大学, 医学部, 教授 (20227408)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 悪性胸膜中皮腫 / CD146 / 早期診断 / 予後因子

Outline of Final Research Achievements

CD146, a cell adhesion molecule, was expressed in 85% of malignant pleural mesothelioma but not in reactive mesothelium. The level of soluble form of CD146 was significantly higher in pleural effusions of malignant pleural mesothelioma than those of benign diseases such as pleuritis. In addition, the postoperative overall survival of patients with high expression of CD146 in malignant pleural mesothelioma was significantly shorter than that with low expression of CD146. These results suggest that CD146 is useful in early diagnosis and associated with poor prognosis of malignant pleural mesothelioma.

Free Research Field

医歯薬学