2014 Fiscal Year Final Research Report
The assessment of malignant degree of carcinoma based on histological and biological factors of carcinoma.
| Project/Area Number |
24590439
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Saitama Medical University (2013-2014)
National Center of Neurology and Psychiatry (2012) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 乳癌 / 癌間質 / 癌悪性度 / 異型腫瘍間質線維芽細胞 / リンパ管腫瘍塞栓 / 静脈腫瘍塞栓 |
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| Outline of Final Research Achievements |
The present study clearly demonstrated that the best factor for accurately predicting locoregional recurrence was grade 3 lymph vessel tumor embolus, followed by type 2 invasive ductal carcinoma, grade 2 lymph vessel tumor embolus, primary invasive tumor cell-related factors and >5 mitotic figures in metastatic carcinomas to the lymph node.
We classified 263 invasive ductal carcinomas into the following three grades according to the numbers of mitotic and apoptotic figures in tumor cells located in blood vessels within 1 high-power field: grade 0, grade 1, and grade 2. Multivariate analyses with well-known prognostic factors demonstrated that grade 2 blood vessel tumor emboli significantly increased the hazard ratios for tumor recurrence independent of the nodal status, pathological TNM stage, hormone receptor status or HER2 status.
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| Free Research Field |
人体病理学
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