Histological comparison of fibroblastic stromal cells in cancer microenvironment

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590442
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Tohoku University
• Principal Investigator: MIKI Yasuhiro 東北大学, 災害科学国際研究所, 講師 (50451521)
• Research Collaborator: HATA Shuko 東北大学, 医学系研究科, ポスドク (90466532)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 癌間質細胞 / 肺癌 / 乳癌 / 癌間質相互作用 / 血管新生

Outline of Final Research Achievements

It is well known that intratumoral stromal cells exert important role on cancer proliferation and invasion in several types of cancer. However, the histological differences in the cell growth and angiogenesis of cancer remain unclear. In this study, we established fibroblast-like stromal cell (FSC) derived from breast and lung carcinoma tissues, respectively. There were no differences in the cancer cell growth between the FSC derived from squamous cell carcinoma and adenocarcinoma of the lung, but considerable differences in tubular formation of endothelial cells were observed between the two histologic types.

Free Research Field

腫瘍病理学