2014 Fiscal Year Final Research Report
Molecular mechanism of OLFM4 and the significance as an inflammatory biomarker and therapeutic target for ulcerative colitis
| Project/Area Number |
24590452
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SAEGUSA Makoto 北里大学, 医学部, 教授 (00265711)
OKAYASU Isao 北里大学, 医学部, 名誉教授 (20014342)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 潰瘍性大腸 / 炎症性腸疾患 / 発現 / 炎症 / OLFM4 / olfactomedin-4 / アポトーシス |
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| Outline of Final Research Achievements |
We analyzed olfactomedin-4(OLFM4), a molecule specifically upregulated in ulcerative colitis by the comprehensive analysis of UC and its associated tumorigenesis. We aimed to show that OLFM4 was a specific inflammatory biomarker for inflammatory bowel diseases (IBDs).
(1)OLFM4 was specifically expressed in UC and Crohn disease(CD), which shows that OLFM4 is and specific biomarker for IBDs. (2)OLFM4 is transcriptionally induced by NF-kB, (3)with the different mechanism in UC and CD. (4)We also showed the possibility of pro-apoptotic function of OLMF4 in the enterocytes.
In IBDs, apoptosis of enterocytes would be induced by the expression of OLFM4, with the abnormality of enterobacterial flora, which might be the cause of dysfunction of barrier effects of enterocytes.
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| Free Research Field |
人体病理学
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