2014 Fiscal Year Final Research Report
Expression analysis of hWAPL oncogene
| Project/Area Number |
24590453
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KURODA Masahiko 東京医科大学, 医学部, 教授 (80251304)
KURATA Atsushi 東京医科大学, 医学部, 准教授 (10302689)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | hWAPL / 子宮頸部病変 / HPV |
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| Outline of Final Research Achievements |
By use of immunohistochemical method, we showed that the expression of hWAPL protein increases in the cervical lesion. The expression of hWAPL protein increased as the cervical lesion progresses from mild dysplasia (CIN1) to severe dysplasia (CIN3) and carcinoma. This indicates that hWAPL protein is important to form cervical lesions.
We also demonstrated that the detection of mRNA of human papilloma virus (HPV), which is associated with cervical lesions and the expression of hWAPL, is more specific than that of DNA.
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| Free Research Field |
腫瘍病理学
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