2014 Fiscal Year Final Research Report
Cancer Microenvironment formed by peritoneal invasion enhance tumor progression through the activation of subperitoneal fibroblast.
Project/Area Number |
24590458
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | National Cancer Center Japan |
Principal Investigator |
MOTOHIRO Kojima 独立行政法人国立がん研究センター, その他部局等, その他 (30338470)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
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Keywords | 人体病理学 / 大腸がん / 癌微小環境 |
Outline of Final Research Achievements |
We reported firstly that peritoneal elastic laminal invasion (ELI) in colon cancer is the strong prognostic factor. This report is going to get world-wide consensus, and upstaging of pT3 colon cancer with ELI is proposed. Furthermore, we found morphologically distinct tumor microenvironment was formed in tumor area with peritoneal invasion, and defined it as cancer microenvironment formed by peritoneal invasion (CMPI). We propagated subperitoneal fibroblast (SPF) from human peritoneum, and found that SPF is characterized by the robust gene overexpression by cancer medium stimulation. Using in vivo mouse model co-injected with subperitoneal fibroblast and cancer cells, we found that SPF actively promote tumor progression and metastasis. Together with these findings, SPF plays crucial role in cancer progression and metastasis in tumor area of CMPI.
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Free Research Field |
人体病理学
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