Analysis of mitochondria D-loop DNA/RNA

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590459
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses
• Principal Investigator: TOMITA Yasuhiko 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), その他部局等, その他 (60263266)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ミトコンドリア / ＶＣＰ / ＵＢＬ４Ａ / 発癌

Outline of Final Research Achievements

To clarify the distribution pattern of mitochondrial DNA and RNA in cultured cells, in situ hybridization and polymerase chain reaction was performed. However no distinct observation was obtained.
Ubiquitin like 4A (UBL4A) is a cofactor of valosin containing protein (VCP), which is associated with cancer metastasis. Inhibitory effect of UBL4A in STAT signaling was found. Chronic inflammation with steatosis of the pancreas appears to be an important predisposing factor for pancreatic cancer.

Free Research Field

人体病理学