Regulation of hematopoietic stem/progenitor cell (HSPC) cycle via HSPC niches, the site of xenobiotic interrelationship, in relation to natural aging

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590467
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: National Institute of Health Sciences
• Principal Investigator: HIRABAYASHI Yoko 国立医薬品食品衛生研究所, 安全性生物試験研究センター毒性部, 室長 (30291115)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 造血幹・前駆細胞 / 幹細胞ニッチ / 生体異物相互作用 / 細胞周期 / 酸化ストレス

Outline of Final Research Achievements

The aims of this study were to focus on and analyze the hematopoietic regulatory system on the basis of three aspects, specifically focusing on a system that maintains hematopoietic stemness via hematopoietic stem/progenitor cell (HSPC) niches, the site of xenobiotic interrelationship. The first aim was to analyze the system during the dormancy period of HSPCs using several gene-modified mice with impaired hematopoiesis. The second aim was to examine the cellular and molecular mechanisms related to hematopoietic kinetic changes under oxidative stresses (e.g. induced by whole-body irradiation or benzene treatment). The third aim was to examine changes in the cell-cycle fraction during the senescent stage solely in relation to natural aging or in the presence of additional oxidative stresses such as those mentioned above. As a result, a functionally different regulatory/protecting systems were supposed to be present depending on the differentiation status of HSPCs.

Free Research Field

幹細胞病理（造血幹細胞機能調節異常）