2015 Fiscal Year Final Research Report
Development of histologically accurate brain tumor mouse models for preclinical trial
| Project/Area Number |
24590478
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Experimental pathology
|
|---|
| Research Institution | The University of Tokyo (2014-2015)
Nagoya University (2012-2013) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2016-03-31
|
| Keywords | 脳腫瘍 / マウスモデル / 前臨床試験 / 生体イメージング / 神経膠腫 / 髄芽腫 / トランスレーショナルリサーチ |
|---|
| Outline of Final Research Achievements |
Malignant brain tumors are the most devastating human cancers and accurate mouse models of these tumors are essential in order to develop optimal therapies. The RCAS/tv-a mouse model system is used to create histologically accurate brain tumors by RCAS virus-mediated gene transfer into the brain cells expressing tv-a receptor. I have introduced and established these mouse models first in Japan, successfully developed brain tumors in mice, and investigated drug efficacy and the mechanisms of tumorigenesis. These results will further expand the research on brain tumor biology and the development of new treatments for brain tumors.
|
| Free Research Field |
脳腫瘍
|
