Study on cell transition in renal tubulointerstitial fibrosis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590488
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Wakayama Medical University
• Principal Investigator: MURAGAKI Yasuteru 和歌山県立医科大学, 医学部, 教授 (40190904)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 腎間質線維化 / 上皮間葉移行 / TGF-β / Klotho / ビタミンD / リン・カルシウム代謝

Outline of Final Research Achievements

In renal tubulointerstitial fibrosis, tubular epithelial cells are stimulated by various factors and transform from epithelial cells to mesenchymal cells. This epithelial to mesenchymal transition is caused by transforming growth factor (TGF) - beta, which promotes interstitial fibrosis. In this study, we forcused on the relationship between phosphate/calcium metabolism and renal interstitial fibrosis and investigated how a loss of Klotho influenced the degree of fibrosis. As a result, we found that the total loss of Klotho increases the active form of vitamin D, which in turn inhibits TGF-beta signaling, resulting in suppressing tubulointerstitial fibrosis.

Free Research Field

実験病理学