Functional analysis of LPA receptors in the acquisition of malignant properties in cancer cells.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590493
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Kinki University
• Principal Investigator: TSUJIUCHI Toshifumi 近畿大学, 理工学部, 教授 (10254492)
• Co-Investigator(Kenkyū-buntansha): HONOKI Kanya 奈良県立医科大学, 医学部, 講師 (40336863)
• Co-Investigator(Renkei-kenkyūsha): FUKUSHIMA Nobuyuki 近畿大学, 理工学部, 准教授 (10254161)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: LPA受容体 / がん浸潤 / がん転移 / 抗がん剤耐性 / 血管新生

Outline of Final Research Achievements

Lysophosphatidic acid (LPA) is one of extracellular physiological lipids and interacts with G protein-coupled transmembrane LPA receptors (LPA receptor-1 (LPA1) to LPA6). LPA receptors regulate a variety of biological functions through the binding of LPA, such as cell proliferation, migration, morphogenesis and differentiation. In this study, to assess an involvement of LPA receptors in the acquisition of malignant potency, we generated LPA receptor knockdown cells and measured cell motile and invasive activities, tumorigenicity and angiogenic activity of cancer cells. The present results demonstrate that each LPA receptor acts as a positive or negative regulator of tumor progression, dependent on types of cancer cells. Therefore, it is suggested that LPA signaling via LPA receptors may be a target molecule for the establishment of chemoprevention agents in clinical cancer therapy.

Free Research Field

分子腫瘍学