Analysis of gene expression on interstitial cells of Cajal

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590494
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Hyogo Medical University
• Principal Investigator: ISOZAKI Koji 兵庫医科大学, 医学部, 非常勤講師 (00425117)
• Co-Investigator(Kenkyū-buntansha): HIROTA Seiichi 兵庫医科大学, 医学部, 教授 (50218856)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: カハールの介在細胞 / c-kit / GISTs / CADM1

Outline of Final Research Achievements

By using cDNA library of interstitial cells of Cajal(ICCs), we first clarified that CADM1, one of cell adhesion molecules, is specifically expressed by ICCs. We investigated CADM1 expression in gastrointestinal stromal tumors (GISTs) which are considered to be originated from ICCs, and found that most of GISTs in the small intestine express CADM1, but most of gastric GISTs do not. The specific expression of CADM1 in small intestinal GISTs might mean that specific expression of CADM1 in ICCs in the small intestine. ICCs in different sites may show different protein expression pattern and may have different role.

Free Research Field

病理学