Induction of transplantable myogenic cells from pluripotent stem cells

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590497
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: SUZUKI Yuko 独立行政法人国立精神・神経医療研究センター, 神経研究所・遺伝子疾患治療研究部, 室長 (00342931)
• Co-Investigator(Kenkyū-buntansha): TAKEDA Shin'ichi 国立精神・神経医療研究センター, 神経研究所・遺伝子疾患治療研究部, 部長 (90171644)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 幹細胞 / 再生医療 / iPS細胞 / ジストロフィン

Outline of Final Research Achievements

Induced pluripotent stem cells are a promising tool for regenerative medicine of muscular dystrophies. Here, we compared the cell surface antigens on human myoblasts and human fibroblasts, and found that CD56 and CD271 specifically recognize human myoblasts. Next, we tested whether EZ-sphere method is effective to induce transplantable muscle stem/progenitor cells by transplantation into immunodeficient mdx mice (DMD model mice) and found that iPS-derived muscle stem/progenitor cells participate in muscle regeneration.

Free Research Field

筋ジストロフィー