Investigation of mechanisms to keep blood vessels patent in hepatocellular carcinoma.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590499
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Kanagawa Cancer Center Research Institute
• Principal Investigator: MIYAGI Yohei 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), その他部局等, 総括部長 (00254194)
• Co-Investigator(Kenkyū-buntansha): KOIZUME Shiro 神奈川県立がんセンター臨床研究所, 主任研究員 (60416063)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 凝固第VII因子 / 組織因子 / 凝固 / 肝がん / TFPI / TF / fVII

Outline of Final Research Achievements

Hepatocellular carcinoma (HCC) cells produce both blood coagulation factor-VII (fVII) and tissue factor (TF). We clarified in the present study that under such circumstances, HCC cells do not elicit TF-fVIIa blood coagulation pathway because of ectopic tissue factor pathway inhibitor (TFPI)-1 production. At least in HCC cells, there exist a mechanism to keep patency of tumor vessels, that could be a good target for novel anticancer therapy.

Free Research Field

分子腫瘍学・病理学