2015 Fiscal Year Final Research Report
Immuno-modulator effects of the apyrase derived from Toxoplasma gondii
| Project/Area Number |
24590512
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ONO Yasuo 帝京大学, 医学部, 教授 (10177272)
UBAGAI Tsuneyuki 帝京大学, 医学部, 講師 (10311416)
KIKUCHI Hirotoshi 帝京大学, 医学部, 准教授 (80338681)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 原虫 / 免疫調節 |
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| Outline of Final Research Achievements |
Immuno-modulate effects of T. gondii NTPase on neutrophils or mast cells were examined in this research project. When neutrophils or mast cells were exposed with ATP in vitro, gene expressions of TNF-α and IL-8 were down-regulated. However, presence of NTPase with ATP neutralized those effects of down-regulation. Gene expression of CD39 that is as known as ecto ATPase in neutrophil were also decreased. Neutrophils exposed both of ATP and NTPase showed that the equal CD39 expression with control. The mRNA expression of an adenosine receptor, AdoRA2a was down-regulated by NTPase. No effects of ATP or NTPase were observed in CD73 expression. It is suggested that T. gondii might use NTPase as an immune-modulator to escape from neutrophils or other immune cells in infection.
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| Free Research Field |
医歯薬学
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