2014 Fiscal Year Final Research Report
Analysis of factors involvement of specificity of phagocytosis in Entamoeba histolytica
| Project/Area Number |
24590514
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 分子 / Rab GTPase / 貪食 / 小胞体 |
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| Outline of Final Research Achievements |
Phagocytosis is indispensable for the pathogenesis of the intestinal protozoan parasite Entamoeba histolytica. This report showed that in E. histolytica Rab8A, which is generally involved in trafficking from the trans-Golgi network to the plasma membrane in other organisms, but was previously identified in phagosomes of the ameba in the proteomic analysis, primarily resides in the endoplasmic reticulum (ER) and participates in phagocytosis.
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| Free Research Field |
細胞生物学
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