2014 Fiscal Year Final Research Report
New biologicol activity of staphylococcal enterotoxin: Elucidation of neurotoxic effects and its mechanism
| Project/Area Number |
24590516
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | エンテロトキシン / ブドウ球菌 / 病原性 |
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| Outline of Final Research Achievements |
Staphylococcal enterotoxin (SE) is an important bacterial toxin that involved in human diseases including food poisoning and toxic shock syndrome. We have been studied the emetic activity and its mechanism of SE, used a small vomiting animal model, house musk shrews. In this study, a new feature-neurotoxic effects of SE were studied. In house musk shrews experiments, SE showed vomiting activity, but it does not have the diarrhea activity. The vomiting of house musk shrews was also inhibited by administering antagonists of nerve cell receptors. In addition, we examined the binding of the toxin and the nerve cells in culture,the release with the production of such 5-HT in the cells.SE did not show toxicity in nerve cells, but it binds to neuronal cells, stimulates cellular signal transduction material, and revealing the SE has neuronal intracellular signal redulatory functions.
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| Free Research Field |
医歯薬学
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