2013 Fiscal Year Final Research Report
Research on the regulatory mechanism of MRSA virulence by mobile genetic elements
| Project/Area Number |
24590519
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KAITO Chikara 東京大学, 薬学研究科(研究院), 准教授 (60420238)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 機能性RNA / メチシリン耐性黄色ブドウ球菌 / 病原性 |
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| Research Abstract |
This study identified a target molecule of a regulatory RNA that methicillin-resistant Staphylococcus aureus (MRSA) carries. The regulatory RNA targets mRNA encoding an essential virulence factor of S. aureus, inhibits its translation, and attenuates S. aureus virulence. This finding suggests a novel molecular mechanism that MRSA decreases the virulence by itself.
This study also revealed that MRSA strains that do not express the regulatory RNA cause a severe disease at higher rate than MRSA strains that express the regulatory RNA. This finding suggests that examination of the expression of regulatory RNA is useful to predict the severity of MRSA diseases.
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[Journal Article] Mobile genetic element SCCmec-encoded psm-mec RNA suppresses translation of agrA and attenuates MRSA virulence2013
Author(s)
Kaito C,Saito Y,Ikuo M,Omae Y,Mao H,Nagano G,Fujiyuki T,Numata S,Han X,Obata K,Hasegawa S,Yamaguchi H,Inokuchi K,Ito T,Hiramatsu K,Sekimizu K
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Journal Title
PLoS Pathog
Volume: 9(4)
Pages: e1003269
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[Journal Article] Impact of psm-mec in the Mobile Genetic Element on the Clinical Characteristics and Outcome of SCCmec-II Methicillin-resistant Staphylococcus aureus Bacteremia in Japan
Author(s)
Aoyagi T,Kaito C,Sekimizu K,Omae Y,Saito Y,Mao H,Inomata S,Hatta M,Endo S,Gu Y,Tokuda K,Yano H,Kitagawa M,Kaku M
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Journal Title
C1in Microbio1 Infect
Volume: (in press)
DOI
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[Presentation] 新規機能性RNA psm-mecはagrA遺伝子の翻訳を抑制してメチシリン耐性黄色ブドウ球菌の病原性を抑制する2013
Author(s)
幾尾真理子,斎藤裕樹,大前陽輔,毛翰,長野源太郎,藤幸知子,沼田俊介,韓笑,小幡佳津明,長谷川節雄,山口博樹,猪口孝一,伊藤輝代,平松啓一,伊藤孝司,関水和久,垣内力
Organizer
第86回日本生化学会大会
Place of Presentation
神奈川(横浜)
Year and Date
20130911-13
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