2014 Fiscal Year Final Research Report
Regulation of autophagy by endogenously produced hydrogen sulfide anion and its physiological functions
| Project/Area Number |
24590527
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
|
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| Research Institution | Tohoku University (2014)
Kumamoto University (2012-2013) |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 硫化水素 / オートファジー / 感染防御 / 細菌 / 病原性 |
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| Outline of Final Research Achievements |
The present study revealed that a sulfur-containing compound cysteine persulfide and a nitrated cyclic nucleotide 8-nitro-cGMP are involved in the regulation of autophagy and antibacterial host defense. Also, it showed that hydrogen sulfide produced by bacteria inhibits the autophagy induction in host cells and may contribute to the growth of bacteria in infected cells.
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| Free Research Field |
細菌学
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