Role on pathogenesis of antigenic diversity of lipopolysaccharides in Helicobacter pylori infection

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590530
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Bacteriology (including Mycology)
• Research Institution: Sapporo Medical University
• Principal Investigator: YOKOTA Shin-ichi 札幌医科大学, 医学部, 教授 (10325863)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Soh 札幌医科大学, 医学部, 助教 (10588479) ; FUJII Nobuhiro 札幌医科大学, 医学部, 教授 (90133719)
• Research Collaborator: KONNO Mutsuko 札幌厚生病院, 小児科 ; FUJIWARA Shin-ichi 札幌厚生病院, 小児科 ; TOITA Nariaki 札幌厚生病院, 小児科
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ヘリコバクター・ピロリ / 感染免疫 / リポ多糖 / 炎症 / エピトープ / 発癌

Outline of Final Research Achievements

Helicobacter pylori lipopolysaccharide (LPS) can divide highly-antigenic epitope-carrying one and weakly-antigenic epitope-carrying one. We found that weakly-antigenic epitope-carrying LPS enhanced Escherichia coli LPS-induced IL-8 production by upregulation of Toll-like receptor 4 expression in cooperation with host surfactant protein D, which specifically interacted with the weakly-antigenic LPS. The weakly-antigenic LPS-carrying H. pylori is more frequently found in gastric tumor than other gastroduodenal diseases. In this study, we did not observe relationship between the antigenicity of LPS and pathogenesis of H. pylori-related iron deficiency anemia.

Free Research Field

微生物学，免疫学，生化学