2014 Fiscal Year Final Research Report
Functional analysis of Salmonella type III effectors, which are involved in evading the host innate immune response.
| Project/Area Number |
24590534
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | サルモネラ / III型エフェクター / 自然免疫 |
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| Outline of Final Research Achievements |
In this study, we demonstrated that Salmonella anti-inflammatory type III effector SpvC, a phosphothreonine lyase, contributes to bacterial proliferation in the spleen in the mouse model of systemic infection. We also revealed that other Salmonella type III effectors, SseK1, SseK2 and SseK3, regulate NF-κB activation in the host cell.
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| Free Research Field |
医歯薬学
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