Cell cycle-related protein kinase in Aspergillus fumigatus

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590546
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Bacteriology (including Mycology)
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: UMEYAMA Takashi 国立感染症研究所, その他部局等, 研究員 (20360696)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: Aspergillus fumigatus / アスペルギルス症 / シグナル伝達 / プロテインキナーゼ / 病原真菌 / 真菌症 / 糸状菌 / 細胞周期

Outline of Final Research Achievements

Overall mortality with invasive pulmonary aspergillosis was over 50%, leading to strong expectation for development of a novel therapeutics. Aim of study is to elucidate correlation between cell cycle regulation and filamentous growth via analysis of protein kinases in Aspergillus fumigatus, the major causative agent of aspergillosis. I analyzed 8 protein kinases by inhibitors, gene disruption, gene downregulation, and chemical genetics. I found that Mps1 are essential for the growth. These results could contribute to basic research for a novel therapeutics of aspergillosis and give a new insight of unique mechanism for cell cycle regulation into basic biology field.

Free Research Field

医真菌学