2014 Fiscal Year Final Research Report
Cell cycle-related protein kinase in Aspergillus fumigatus
Project/Area Number |
24590546
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Bacteriology (including Mycology)
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Research Institution | National Institute of Infectious Diseases |
Principal Investigator |
UMEYAMA Takashi 国立感染症研究所, その他部局等, 研究員 (20360696)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | Aspergillus fumigatus / アスペルギルス症 / シグナル伝達 / プロテインキナーゼ / 病原真菌 / 真菌症 / 糸状菌 / 細胞周期 |
Outline of Final Research Achievements |
Overall mortality with invasive pulmonary aspergillosis was over 50%, leading to strong expectation for development of a novel therapeutics. Aim of study is to elucidate correlation between cell cycle regulation and filamentous growth via analysis of protein kinases in Aspergillus fumigatus, the major causative agent of aspergillosis. I analyzed 8 protein kinases by inhibitors, gene disruption, gene downregulation, and chemical genetics. I found that Mps1 are essential for the growth. These results could contribute to basic research for a novel therapeutics of aspergillosis and give a new insight of unique mechanism for cell cycle regulation into basic biology field.
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Free Research Field |
医真菌学
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