Understanding of mechanisms of avian influenza virus adaptation to humans.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590549
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Virology
• Research Institution: The University of Tokyo
• Principal Investigator: YAMADA SHINYA 東京大学, 医科学研究所, 助教 (90466839)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: インフルエンザ / 適応

Outline of Final Research Achievements

To better understand how H5N1 influenza viruses could become to replicate and transmit efficiently among humans, we analyzed mutations occurred in H5N1 viruses through the adaptation to normal human bronchial epithelial (NHBE) cells. We found some HA mutations responsible for the efficient replication in NHBE cells affected thermal stability, fusion activity and cytotoxicity, suggesting such mutations might confer the phenotype of seasonal human viruses to avian H5N1 viruses.

Free Research Field

ウイルス学