2014 Fiscal Year Final Research Report
A study to lower a viral mutation rate
| Project/Area Number |
24590552
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Graduate School of Health Care Science, Jikei Institute (2014)
Kobe University (2012-2013) |
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Principal Investigator |
TANAKA Kyoko 滋慶医療科学大学院大学, 医療管理学研究科, 教授 (90374925)
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| Research Collaborator |
SASAHARA Kenji
SUZUKI Yasuhiro
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | ウイルス / 遺伝子変異 / 進化 |
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| Outline of Final Research Achievements |
A candidate host factor which may contribute to alter the mutation rate of the virus polymerase was explored in the early experiment. As a series of the experiments, virus factor which may affect mutation rate was sought by comparing a pair viruses derived from the same lineage. These viruses showed a different tendency of mutation under certain environment of selective pressure. With the aim of discovering the genetic predisposition, we conducted Next-generation DNA sequencing against them and plotted the gene mutation. Currently we are comparing these ascertained mutation genes with gene sequences in the database.
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| Free Research Field |
生物計算学
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