Defensive mechanism of interferon-regulatory factors (IRFs) via trypsinogens against virus infection.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590555
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Virology
• Research Institution: Nagasaki University
• Principal Investigator: HAYASHI Hideki 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (10218589)
• Co-Investigator(Kenkyū-buntansha): KUBO Yoshinao 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (30273527)
• Co-Investigator(Renkei-kenkyūsha): MATSUYAMA Toshifumi 長崎大学, 医歯薬学総合研究科(医学系), 教授 (30165922)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: インフルエンザウイルス / トリプシノーゲン / エンテロキナーゼ / インターフェロン調節因子(IRFs) / インターフェロン誘導遺伝子(ISGs)

Outline of Final Research Achievements

We have shown the expressions of enterokinase in many human cells other than duodenal cells where it activates trypsinogens secreted from the pancreas. In addition, some types of trypsinogens are reported to exist in many cells as well as pancreatic cells. Our data indicated that the enterokinase significantly enhanced the influenza A virus infection by activating the trypsinogens. The enterokinase-mediated activation of trypsinogens could be a target for the development of new anti-viral reagents against influenza A virus.

Free Research Field

医歯薬学