2014 Fiscal Year Final Research Report
Clarification of the mechanistic analysis of the samll RNA derived from HBV geneome and its asociation for hepatocarcinogenesis
| Project/Area Number |
24590559
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAKIZAWA Toshihiro 日本医科大学, 大学院医学研究科, 教授 (90271220)
DEMETRIS Anthony J University of Pittsburgh Pathology, Professor
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | microRNA / HBV |
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| Outline of Final Research Achievements |
We constructed a plasmid vector that was expressing 26nt RNA that might be derived from HBV genome, and we transfected the vector in to the HCC cell line HepB3 cells.Unfortunately, we did not detected the expression of the 26nt small RNA in the cell line.
We also constructed stably expressing cell lines. Some of them did EMT by the transfection, which indicated that the small RNA had a potential for initiate EMT by undetermined mechanism.
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| Free Research Field |
消化器外科
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