2014 Fiscal Year Final Research Report
Characterization of cellular phenotypes specific for the ATL development in HTLV-1 infected humanized mouse
| Project/Area Number |
24590562
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | ウイルス / ATL / 動物モデル / HTLV-1 |
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| Outline of Final Research Achievements |
Tumorigenesity of CD25-negative and -positive CD4 T cells isolated from HTLV-1-infected humanized mice that exhibit ATL-like symptoms was examined by transplanting cells to the spleen of NOG mouse and only CD25-positive HTLV-1-infected CD4 T cells was found to form tumor. cDNA microarray analysis demonstrated that several genes related to the regulatory T-cells and a cellular mutator gene, APOBEC3B, were activated upon HTLV-1 infection. Genes for BATF3 and SYK were upregulated in parallel with the expression of CD25. Since no sign of mutation in the level of host genome was detected, the epigenetic modifications are suggested to be mainly involved in the leukemogenesis of HTLV-1 infected humanized mouse.
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| Free Research Field |
ウイルス腫瘍学
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