2014 Fiscal Year Final Research Report
Cis/Trans-acting elements that regulate EBV reactivation from latency and epigenetics
| Project/Area Number |
24590566
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Nagoya University (2013-2014)
愛知県がんセンター(研究所) (2012) |
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Principal Investigator |
MURATA Takayuki 名古屋大学, 医学(系)研究科(研究院), 准教授 (30470165)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 再活性化 |
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| Outline of Final Research Achievements |
We here analyzed the molecular mechanisms that govern reactivation of Epstein-Barr virus (EBV) from latency. Research like this is of significance, because EBV reactivation contributes not only to virus spreading but also to pathogenesis of EBV-related cancers.
Reactivation of EBV is dependent on the expression of viral immediate-early gene, BZLF1. We thus analyzed the promoter region of BZLF1 gene. Through exhaustive functional cloning, we here identified host factors that can induce EBV reactivation, and even more, we observed epigenetic modification of the promoter that associates with reactivation.
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| Free Research Field |
ウイルス学
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