2014 Fiscal Year Final Research Report
Functional analysis of neurite outgrowth inhibitor proteins in B cell activation
| Project/Area Number |
24590572
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Tohoku University |
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Principal Investigator |
INUI Masanori 東北大学, 加齢医学研究所, 講師 (80443985)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | B細胞 / 免疫寛容 / TLR |
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| Outline of Final Research Achievements |
In this study, I examined the physiological roles of neurite outgrowth inhibitor protein Nogo and Nogo receptor (NgR1) in B cell activation. Nogo-deficient B cells showed a significant reduction of IL-6 and IgM production in response to LPS, CpG and poly(I:C). Thus, Nogo was indispensable for full activation of nucleic acid-sensing TLR responses in B cells.
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| Free Research Field |
免疫学
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