Analyses of interaction between IL-18-induced helper NK cells and cytotoxic gamma delta T cells

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590581
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Immunology
• Research Institution: Nagasaki University
• Principal Investigator: TANAKA Yoshimasa 長崎大学, 医歯(薬)学総合研究科(薬学系), 准教授 (90280700)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: γδ型T細胞 / ブチロフィリン / 抗原 / イソペンテニルピロリン酸

Outline of Final Research Achievements

It was demonstrated that butyrophilin 3A1 played a critical role in the recognition by human gamma delta T cells of specific antigens. The present study suggests that a change in the structure of extracellular domain of butyrophilin 3A1 induced by binding of intracellularly accumulated isopentenyl diphosphate to intracellular domain of butyrophilin 3A1 is recognized by the human gamma delta T cell receptor. This finding argues that alternative systems of specific T cell recognition, complementing those for major histocompatibility complex-involved peptide antigen recognition by alpha beta T cells, exist for nonpeptide antigen-recognition by human gamma delta T cells.

Free Research Field

免疫学