2014 Fiscal Year Final Research Report
Analysis of innate immune cells in small intestinal lamina propria
| Project/Area Number |
24590582
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
|
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 粘膜免疫 / 自然免疫 / Toll-like receptor |
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| Outline of Final Research Achievements |
We examined expression of TLR family members and cytokine production in macrophage of small intestinel lamina propria. We analyzed dendritic cells in small intestinel lamina propria to develop a new vaccine which can induce mucosal IgA. We also clarified that TLR3 is an exacerbating factor for radiation-induced acute intestinal injury by using TLR3-deficient mice. We further clarified that eosinophils play essential roles for intestinal fibrosis after abdominal irradiation.
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| Free Research Field |
免疫学
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