2014 Fiscal Year Final Research Report
Characterization of KDEL receptor that regures T cell survival
| Project/Area Number |
24590583
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
|
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| Research Institution | Hokkaido University (2014)
Osaka University (2012-2013) |
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Principal Investigator |
|
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | T細胞 |
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| Outline of Final Research Achievements |
T cells are a central player in the acquired immune system, and their numbers are regulated to be constant in vivo. It has been known that the maintenance of this T-cell homeostasis is mediated by survival signals from cytokine IL-7 and T-cell receptor:MHC interactions. In this study, using a mutant mouse line, called T-Red, it is shown that the T-cell homeostasis is established by a balance between the survival signals and a death signal induced by integrated stress responses.
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| Free Research Field |
免疫学
|
