2014 Fiscal Year Final Research Report
Significance of necrosis DNA fragmentation under oxidative stress and immune response
| Project/Area Number |
24590587
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | Tokyo University of Science |
|---|
Principal Investigator |
MIZUTA RYUSHIN 東京理科大学, 生命医科学研究所, 准教授 (50297628)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | ネクローシス / DNA断片化 / 酸化ストレス / 自己免疫疾患 / SLE |
|---|
| Outline of Final Research Achievements |
Using specific inhibitors, we revealed that Acrolein, a low molecular-weight aldehyde produced under oxidative stress, is an exacerbation factor of acetaminophen-induced liver failure in mouse. From the analysis of DNase γ gene knock-out mouse, we also found that DNase γ cooperates with DNase I in inhibiting the liver failure by accelerating DNA degradation and sequestration/removal of dead cells.
|
| Free Research Field |
医歯薬学
|
