Development of pharmacological therapy targeting peripheral circadian clocks for treatment of type 2 diabetes

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590666
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Jichi Medical University
• Principal Investigator: ANDO Hitoshi 自治医科大学, 医学部, 准教授 (50382875)
• Co-Investigator(Renkei-kenkyūsha): USHIJIMA Kentaro 自治医科大学, 医学部, 講師 (70448843) ; TAKAMURA Toshinari 金沢大学, 医薬保健研究域医学系, 教授 (00324111)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 体内時計 / 概日リズム / 時計遺伝子 / 糖尿病 / 生活習慣病 / 糖新生 / 暁現象

Outline of Final Research Achievements

Recent studies have indicated that disrupted circadian clocks in peripheral tissues (peripheral clocks) are associated with the pathophysiology of lifestyle-related metabolic diseases including type 2 diabetes. To develop a strategy targeting peripheral clocks for treatment/prevention of metabolic diseases, whether exenatide could affect the rhythms of peripheral clocks was investigated in mice, and we found that exenatide modulates peripheral clocks more strongly than feeding. In addition, we evaluated the impact of peripheral clock in the liver and revealed that hepatic clock directly regulates the daily fasting blood glucose rhythm.

Free Research Field

内科学　臨床薬理学