Pathophysiological role of AGEs as exacerbation factor in tissue remodeling and molecular targeted therapy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590672
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Shujitsu University
• Principal Investigator: MORI Shuji 就実大学, 薬学部, 教授 (50220009)
• Co-Investigator(Kenkyū-buntansha): GOMITA Yutaka 就実大学, 薬学部, 元教授 (00088709) ; TOYOMURA Takao 就実大学, 薬学部, 助教 (40425137)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 組織リモデリング / 炎症 / 再生 / サイトカイン / 分子標的

Outline of Final Research Achievements

In this study, we isolated AGEs-binding factor of MW 70kDa by affinity chromatography from lung extract to elucidate the pathophysiological significance of AGEs in inflammatory sites, and to develop the novel targeted therapeutics. The binding between AGEs and RAGE was shown to be inhibited by AGEs-binding factor with dose-dependency, particularly by two different peptides in N-terminal region. These findings indicated the formation of functional complex in several inflammatory conditions.

Free Research Field

薬理学，応用薬理学