Clinicopathological features of malignant lymphoma in Miyagi study

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590677
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Tohoku University
• Principal Investigator: ICHINOHASAMA Ryo 東北大学, 大学病院, 教授 (30184625)
• Co-Investigator(Kenkyū-buntansha): FUKUHARA Noriko 東北大学, 大学病院, 講師 (10534167) ; ISHIZAWA Kenichi 山形大学, 大学院医学系研究科, 教授 (00359506)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 悪性リンパ腫 / 疫学

Outline of Final Research Achievements

A total of 3,043 cases of newly diagnosed malignant lymphoma in Miyagi between 2002 and 2012 were enrolled in this epidemiological study. The rate of each subtype was mostly similar to that in our previous report. The most frequent subtype of B-cell lymphoma was diffuse large B-cell lymphoma (DLBCL), followed by follicular lymphoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (38.6%, 19.7% and 7.5%).
To identify the biological prognostic factors in DLBCL, we analyzed biological parameters (BCL2, BCL6, c-MYC and BACH2). In cases with high BACH2 expression in GCB (38 cases) and non-GCB groups (38 cases), the 3-year overall survival (OS) rate was significantly shorter than that with low expression (71.7% vs 91.3%, P = 0.0256). In the DLBCL with MYC translocation (n=18), expression of BACH2 may be a prognostic marker (3y OS 75.0% vs 22.9%, P=0.132). BACH2, a B cell-specific transcriptional repressor, may plays a significant role in B cell lymphoma.

Free Research Field

造血器病理学