2014 Fiscal Year Final Research Report
Detection of pathogenic activity of the autoantibodies in SLE and antiphospholipid syndrome
| Project/Area Number |
24590681
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KUBOTA Tetsuo 東京医科歯科大学, 大学院保健衛生学研究科, 教授 (90205138)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 全身性エリテマトーデス / 抗リン脂質抗体症候群 / 抗DNA抗体 / 抗リン脂質抗体 |
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| Outline of Final Research Achievements |
The final goal of this study is selective detection of pathogenic autoantibodies in systemic lupus erythematosus and/or antiphospholipid syndrome. For the first step, we studied whether anti-DNA and antiphospholipid antibodies have activities to induce expression of specific molecules which have been suggested to play a role in the pathogenesis.
Some antibodies cross-reactive with DNA and phospholipid induced expression of tissue factor in monocytes, and BAFF or IL-1β in macrophage-like cells, suggesting that these antoantibodies have pathogenic activities.
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| Free Research Field |
免疫血清学
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