The impact of genetic variants of heme oxygenase-1 on transplant outcomes after unrelated bone marrow transplantation and development of new treatment strategy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590684
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Kanazawa University
• Principal Investigator: MORISHITA Eriko 金沢大学, 保健学系, 教授 (50251921)
• Co-Investigator(Kenkyū-buntansha): TAKAMI Akiyoshi 愛知医科大学, 医学部, 教授 (80324078)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ヘムオキシゲナーゼ-1 / 骨髄移植 / 血管内皮細胞傷害 / トロンボモジュリン / 組織因子 / 急性GVHD / 一塩基多型

Outline of Final Research Achievements

We revealed that the THBD gene single nucleotide variation rs3176123 in the donor side influences a risk for acute graft-versus-host disease (GVHD) and the subsequent mortality after unrelated bone marrow transplantation.　We also demonstrated that exposure of radiation on human umbilical vein endothelial cells resulted in significant increases in tissue factor (TF), IL-6, and ICAM-1 mRNA expressions. On the other hand, thrombomodulin (TM) mRNA expression was significantly decreased. Pretreatment of recombinant TM inhibited radiation-induced expression of TF. Recombinant TM would be effective for the prevention of transplant-related complications.

Free Research Field

血栓止血学