2014 Fiscal Year Final Research Report
The molecular mechanism of the linear-log relation between thyrotropin synthesis and T3
| Project/Area Number |
24590689
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUSHITA Akio 浜松医科大学, 医学部附属病院, 助教 (50402269)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 甲状腺刺激ホルモン / 甲状腺ホルモン / 転写因子 / 甲状腺ホルモン受容体 / GATA2 / ネガティブフィードバック / 下垂体 / 副腎皮質刺激ホルモン |
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| Outline of Final Research Achievements |
There is a linear-log relationship between the syntheses of thyroid-stimulating hormone (TSH) in pituitary and serum thyroid hormone (T3, T4) as in the case between the adrenocorticotropic hormone and glucocorticoid. Based on our tethering model where transactivating function of transcription factor GATA2, which is essential for the TSHbeta expression, is interfered with by T3 in the presence of its receptor (TR), we have studied the role of T3-bound TRbeta 2 in the transcriptional auto-regulation of the GATA2 gene. Our current results may provide the insight for the expression of the TSHbeta gene which is negatively regulated by T3 with linear-log relationship.
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| Free Research Field |
内分泌学
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