2014 Fiscal Year Final Research Report
Clarification of the involvement of leptin and ghrelin in cardiovascular dysautonomia and vision for treatment in Parkinson disease.
| Project/Area Number |
24590691
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Horohisa 名古屋大学, 脳とこころの研究センター, 特任教授 (10378177)
HIRAYAMA Masaaki 名古屋大学, 医学系研究科, 准教授 (30283435)
SOBUE Gen 名古屋大学, 医学系研究科, 教授 (20148315)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | パーキンソン病 / 起立性低血圧 / 食事性低血圧 / グレリン / レプチン |
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| Outline of Final Research Achievements |
We evaluated the involvement of leptin and ghrelin in patients with Parkinson's disease. Decrease in systolic blood pressure during the head-up tilt test was associated with low concentration of basic value of leptin and high concentration of basic value of active ghrelin. Decreased activity of sympathetic nerves and vasodilating effects caused by low concentration of leptin and high concentration of active ghrelin may associates with orthostatic hypotension in Parkinson's disease.
Decrease in systolic blood pressure after glucose load was tend to be associated with percentage change of active ghrelin of the glucose load. Ghrelin is appetite stimulant hormone and is considered to decrease after glucose load. But in Parkinson's disease patients’s with postprandial hypotension, this response is impaired and may result in vasodilation.
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| Free Research Field |
神経内科学
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