Monitoring for anticoagulant therapy and mechanism for anticoagulant

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590692
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Mie University
• Principal Investigator: WADA Hideo 三重大学, 医学(系)研究科(研究院), 准教授 (40158704)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 抗Xa活性 / NOAC / 抗凝固療法

Outline of Final Research Achievements

Anti-Xa activity was negatively correlated with weight or surface area of a body. There was no significant difference in Xa activity between with and without thrombosis, but that was markedly high in the patients with major bleeding. Plasma levels of soluble fibrin (SF) and D-dimer were significantly high in the patients with thrombosis, but that was markedly high in those with major bleeding. Soluble platelet membrane glycoprotein VI (sGPVI) as a marker for platelet activation was markedly high in those with thrombosis. Disseminated intravascular coagulation (DIC) score was useful in the monitoring for DIC, and antithrombin, SF and D-dimer were useful in the monitoring for pregnant women.

Free Research Field

検査医学