Contributing rate of environmental factors to clinical laboratory tests based on the data using twins

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590695
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Osaka University
• Principal Investigator: WATANABE MIKIO 大阪大学, 医学(系)研究科(研究院), 准教授 (50294088)
• Co-Investigator(Renkei-kenkyūsha): HAYAKAWA Kazuo 大阪大学, 医学系研究科, 教授 (70142594) ; KATO Kenji 神戸市立看護大学, 准教授 (70458404)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 臨床検査 / 双生児 / 環境因子

Outline of Final Research Achievements

This study was proposed to examine the environmental factors affecting to the clinical laboratory tests using monozygotic twins, who have completely concordant genetic background. We indicated preliminaly that the methylation rates were different among the genotypes of polymorphisms in gene encoding the methylation-related enzymes, and that they can affect to the prognosis of autoimmune thyroid diseases. In addition, we have found 25-30 discordant twin pairs in the positivity of thyroid-specific autoantibodies, and are analyzing the intra-pair differences of methylation rates using these twins.

Free Research Field

臨床検査診断学