The infection by Helicobacter pylori possessing platelet-activating factor influences the acute coronary syndrome (ACS)

2014 Fiscal Year Final Research Report

• Project/Area Number: 24590698
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Kochi University
• Principal Investigator: SUGIURA Tetsuro 高知大学, 教育研究部医療学系, 教授 (50171145)
• Co-Investigator(Kenkyū-buntansha): TAKEUCHI Hiroaki 高知大学, 教育研究部医療学系, 講師 (90346560) ; TAKATA Jun 高知大学, 教育研究部医療学系, 教授 (90206748) ; MORIMOTO Norihito 高知大学, 医学部附属病院, 副技師長 (60398055)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 急性冠症候群 / 血小板 / ヘリコバクター・ピロリ / 菌体膜成分 / 白血球 / 抗凝固剤

Outline of Final Research Achievements

We investigated to determine whether the infection by Helicobacter pylori possessing platelet-activating factor (lpp) influences the clinical pathology of acute coronary syndrome (ACS). Anti-lpp antibody was gained from a rabbit immunized with the lpp-His fusion protein made. In H. pylori infected Mongolian gerbil, the lpp was not found in blood. However, the 20-kDa was detected by western blotting with anti-lpp antibody in only sera from 2 H. pylori infected ACS patients. These indicated that the lpp transmigrates to blood vessels and might influence on the development of ACS.
Moreover, the lpp associated platelet-activating was synergistically enhanced with L-selectin. Our study showed the possibility that the lpp possesses anti-heparin effect and the affinity of lpp for calcium iron influence the platelet-activating.

Free Research Field

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